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Article

Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity

15 Jun 2000

Abstract excerpt

The immune response to oxidized LDL (OxLDL) may play an important role in atherogenesis. Working with apoE-deficient mice, we isolated a panel of OxLDL-specific B-cell lines that secrete IgM Abs that specifically bind to oxidized phospholipids such as 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine (POVPC). These Abs block uptake of OxLDL by macrophages, recognize similar oxidation-specific epitopes...

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PMID: 10862788
DOI: 10.1172/jci8472

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