Article
Neo-self antigens and the expansion of B-1 cells: lessons from atherosclerosis-prone mice.
Current topics in microbiology and immunology - 1 Jan 2000
Silverman G J, Shaw P X, Luo L, Dwyer D, Chang M, Horkko S, Palinski W, Stall A, Witztum J L
Abstract excerpt
The pathogenesis of atherosclerosis involves an inflammatory process that is modulated by the immune system, and within these complex responses we have discerned a possible role for an archetypic B-1 clone. We speculate that due to their immunogenicity and in vivo distribution the "neo"-self determinants created in oxidatively modified LDL are highly stimulatory for certain B-1 cell clones. These neo-self...
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