Article
Protective Role for B-1b B Cells and IgM in Obesity-Associated Inflammation, Glucose Intolerance, and Insulin Resistance.
Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2016
Harmon Daniel B, Srikakulapu Prasad, Kaplan Jennifer L, Oldham Stephanie N, McSkimming Chantel, Garmey James C, Perry Heather M, Kirby Jennifer L, Prohaska Thomas A, Gonen Ayelet, Hallowell Peter, Schirmer Bruce, Tsimikas Sotirios, Taylor Angela M, Witztum Joseph L, McNamara Coleen A
Abstract excerpt
OBJECTIVE: Little is known about the role(s) B cells play in obesity-induced metabolic dysfunction. This study used a mouse with B-cell-specific deletion of Id3 (Id3(Bcell KO)) to identify B-cell functions involved in the metabolic consequences of obesity. APPROACH AND RESULTS: Diet-induced obese Id3(Bcell KO) mice demonstrated attenuated inflammation and insulin resistance in visceral adipose tissue (VAT), and...
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