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Article

B-1b Cells Secrete Atheroprotective IgM and Attenuate Atherosclerosis.

Circulation research - 17 Jul 2015

Rosenfeld Sam M, Perry Heather M, Gonen Ayelet, Prohaska Thomas A, Srikakulapu Prasad, Grewal Sukhdeep, Das Deepanjana, McSkimming Chantel, Taylor Angela M, Tsimikas Sotirios, Bender Timothy P, Witztum Joseph L, McNamara Coleen A

Abstract excerpt

RATIONALE: B cells contribute to atherosclerosis through subset-specific mechanisms. Whereas some controversy exists about the role of B-2 cells, B-1a cells are atheroprotective because of secretion of atheroprotective IgM antibodies independent of antigen. B-1b cells, a unique subset of B-1 cells that respond specifically to T-cell-independent antigens, have not been studied within the context of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26082558
DOI: 10.1161/CIRCRESAHA.117.306044
PMCID: PMC4527334

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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