Article

IgA antibodies against oxidation-specific epitopes are generated by double negative B cells and are associated with impaired lung function in fibrotic interstitial lung diseases

2025-12-02

Abstract excerpt

<h4>Background</h4> Fibrotic interstitial lung diseases (fILD) are characterized by progressive scarring of the lung and high mortality. Oxidation-specific epitopes (OSEs) form on oxidized lipids and proteins, are abundant in lungs of patients with fILD and perpetuate lung injury and fibrosis in animal models. OSE-targeting antibodies bind to OSEs and modulate their downstream effects. The objective of this study...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4861aade-b464-5d10-a5b3-73c1dcc1d0cc
DOI: 10.64898/2025.11.28.691061

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

IgA antibodies against oxidation-specific epitopes are generated by double negative B cells and are associated with impaired lung function in fibrotic interstitial lung diseasesDOI 10.64898/2025.11.28.691061Read

A protective role for B-1 cells and oxidation-specific epitope IgM in lung fibrosisSemantic proximity Read

The Immunome in Two Inherited Forms of Pulmonary Fibrosis.Semantic proximity Read

The Proteomic Profile of Interstitial Lung Abnormalities.Semantic proximity Read

Proteomic profiling of bronchoalveolar lavage fluid uncovers protein clusters linked to survival in idiopathic forms of interstitial lung diseaseSemantic proximity Read

IgG4 <sup>+</sup> plasma cell enrichment and λ-chain-biased BCR remodeling drive low-grade autoimmunity in chronic obstructive pulmonary diseaseSemantic proximity Read

Marginal Zone B cells produce 'natural' atheroprotective IgM antibodies in a T-cell-dependent mannerSemantic proximity Read

Alveolar cell composition in interstitial lung disease and the development of a pulmonary progressive fibrosing phenotype: a retrospective cohort studySemantic proximity Read

Mass cytometry identifies characteristic immune cell subsets in bronchoalveolar lavage fluid from interstitial lung diseasesSemantic proximity Read

COPD is associated with production of autoantibodies to a broad spectrum of self-antigens, correlative with disease phenotype.Semantic proximity Read

Emergence of a senescent and inflammatory pulmonary CD4 <sup>+</sup> T cell population prior to lung allograft failureSemantic proximity Read

Proteomic analysis of transbronchial biopsy tissue reveals a distinct proteome and mechanistic pathways in high-grade eosinophilic inflammation after lung transplantationSemantic proximity Read

Fc Proteoforms of ACPA IgG Discriminate Autoimmune Responses in Plasma and Synovial Fluid of Rheumatoid Arthritis Patients and Associate with Disease ActivitySemantic proximity Read