A genome-wide association study of IgM antibody against phosphorylcholine: shared genetics and phenotypic relationship to chronic lymphocytic leukemia.

doi:10.1093/hmg/ddy094

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Article

A genome-wide association study of IgM antibody against phosphorylcholine: shared genetics and phenotypic relationship to chronic lymphocytic leukemia.

Human molecular genetics - 15 May 2018

Chen Xu, Gustafsson Stefan, Whitington Thomas, Borné Yan, Lorentzen Erik, Sun Jitong, Almgren Peter, Su Jun, Karlsson Robert, Song Jie, Lu Yi, Zhan Yiqiang, Hägg Sara, Svensson Per, Smedby Karin E, Slager Susan L, Ingelsson Erik, Lindgren Cecilia M, Morris Andrew P, Melander Olle, Karlsson Thomas, de Faire Ulf, Caidahl Kenneth, Engström Gunnar, Lind Lars, Karlsson Mikael C I, Pedersen Nancy L, Frostegård Johan, Magnusson Patrik K E

Abstract excerpt

Phosphorylcholine (PC) is an epitope on oxidized low-density lipoprotein (oxLDL), apoptotic cells and several pathogens like Streptococcus pneumoniae. Immunoglobulin M against PC (IgM anti-PC) has the ability to inhibit uptake of oxLDL by macrophages and increase clearance of apoptotic cells. From our genome-wide association studies (GWASs) in four European-ancestry cohorts, six single nucleotide polymorphisms...

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Share to Core Binding Factor Alpha 3 Subunit

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Identifiers

PMID: 29547969
DOI: 10.1093/hmg/ddy094
PMCID: PMC7116597

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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