Article
IgM antibodies against phosphorylcholine promote polarization of T regulatory cells from patients with atherosclerotic plaques, systemic lupus erythematosus and healthy donors.
Atherosclerosis - 1 Jan 2018
Sun Jitong, Lundström Susanna L, Zhang Bo, Zubarev Roman A, Steuer Johnny, Gillgren Peter, Rahman Mizanur, Ajeganova Sofia, Liu Anquan, Frostegård Johan
Abstract excerpt
BACKGROUND AND AIMS: IgM antibodies against phosphorylcholine (anti-PC) are negatively associated with atherosclerosis, cardiovascular disease (CVD) and systemic lupus erythematosus (SLE), where the risk of CVD and atherosclerosis is high. We here study the effects of IgM anti-PC immune regulation. METHODS: Mononuclear leukocytes were isolated from peripheral blood (PBMC) obtained from healthy blood donors, six...
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