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Article

Genetic antagonism and hypermutability in Mycobacterium smegmatis.

Journal of bacteriology - 1 Jun 2000

Karunakaran P, Davies J

Abstract excerpt

Multidrug-resistant strains of Mycobacterium tuberculosis are a serious and continuing human health problem. Such strains may contain as many as four or five different mutations, and M. tuberculosis strains that are resistant to both streptomycin and rifampin contain mutations in the rpsL and rpoB genes, respectively. Coexisting mutations of this kind in Escherichia coli have been shown to interact negatively (S....

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Identifiers

PMID: 10852861
DOI: 10.1128/JB.182.12.3331-3335.2000
PMCID: PMC101878

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Source receipt: pubmed, retrieved 7 Sept 2026.

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