Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of ribosomal RNAs in macrolide resistance.

Molecular microbiology - 1 Nov 1997

Sander P, Prammananan T, Meier A, Frischkorn K, Böttger E C

Abstract excerpt

Macrolides are bacteriostatic antibiotics which interfere with the peptidyltransfer function of the ribosome. We have investigated the molecular mechanisms underlying macrolide resistance in Mycobacterium smegmatis, an eubacterium carrying two rRNA operons. Surprisingly, drug resistance was assoc...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Anti-Bacterial Agents
Share to Chromosomes, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Microbial

Share to Mutation

Share to Mycobacterium

Share to RNA, Bacterial

Share to RNA, Ribosomal, 23S

Source

Identifiers

PMID: 9402018
DOI: 10.1046/j.1365-2958.1997.5811946.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9402018-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of ribosomal RNAs in macrolide resistance.PMID 9402018Read ↗

Mechanisms of streptomycin resistance: selection of mutations in the 16S rRNA gene conferring resistance.Semantic proximity Read ↗

Ribosomal and non-ribosomal resistance to oxazolidinones: species-specific idiosyncrasy of ribosomal alterations.Semantic proximity Read ↗

Single and dual mutations at positions 2058, 2503 and 2504 of 23S rRNA and their relationship to resistance to antibiotics that target the large ribosomal subunit.Semantic proximity Read ↗

Introducing mutations into a chromosomal rRNA gene using a genetically modified eubacterial host with a single rRNA operon.Semantic proximity Read ↗

Ribosomal Mutations Conferring Macrolide Resistance in Legionella pneumophila.Semantic proximity Read ↗

RecA-Mediated gene conversion and aminoglycoside resistance in strains heterozygous for rRNA.Semantic proximity Read ↗

Single 23S rRNA mutations at the ribosomal peptidyl transferase centre confer resistance to valnemulin and other antibiotics in Mycobacterium smegmatis by perturbation of the drug binding pocket.Semantic proximity Read ↗

Diversity of ribosomal mutations conferring resistance to macrolides, clindamycin, streptogramin, and telithromycin in Streptococcus pneumoniae.Semantic proximity Read ↗

A genetic model to investigate drug-target interactions at the ribosomal decoding site.Semantic proximity Read ↗

23S rRNA base pair 2057-2611 determines ketolide susceptibility and fitness cost of the macrolide resistance mutation 2058A-->G.Semantic proximity Read ↗

Deletion of RsmE 16S rRNA methyltransferase leads to low level increase in aminoglycoside resistance in <i>Mycobacterium smegmatis</i>Semantic proximity Read ↗

Loss of U1498 methylation in 16S rRNA by RsmE methyltransferase associates its role with aminoglycoside resistance in mycobacteriaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.