Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Double mutation in DNA gyrase confers moxifloxacin resistance and decreased fitness of Mycobacterium smegmatis.

The Journal of antimicrobial chemotherapy - 1 Jul 2017

Luo Tao, Yuan Jinning, Peng Xuan, Yang Guoping, Mi Youjun, Sun Changfeng, Wang Chuhan, Zhang Chunxi, Bao Lang

Abstract excerpt

Objectives: Ofloxacin and moxifloxacin are the most commonly used fluoroquinolones (FQs) for the treatment of tuberculosis. As a new generation FQ, moxifloxacin has been recommended for the treatment of ofloxacin-resistant TB. However, the mechanism by which ofloxacin-resistant Mycobacterium tuberculosis further gains resistance to moxifloxacin remains unclear. Methods: We used Mycobacterium smegmatis as a model...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Gyrase
Share to Fluoroquinolones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Fitness

Share to Moxifloxacin

Share to Mycobacterium smegmatis

Share to Ofloxacin

Share to Tuberculosis

Share to Tuberculosis, Multidrug-Resistant

Source

Identifiers

PMID: 28387828
DOI: 10.1093/jac/dkx110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Double mutation in DNA gyrase confers moxifloxacin resistance and decreased fitness of Mycobacterium smegmatis.PMID 28387828Read ↗

Epistasis between antibiotic resistance mutations drives the evolution of extensively drug-resistant tuberculosisSemantic proximity Read ↗

Characterization of gyrA and gyrB mutations and fluoroquinolone resistance in Mycobacterium tuberculosis clinical isolates from Hubei Province, China.Semantic proximity Read ↗

Drug resistance, fitness and compensatory mutations in Mycobacterium tuberculosis.Semantic proximity Read ↗

Compensatory mutations are associated with increased in vitro growth in resistant clinical samples of Mycobacterium tuberculosis.Semantic proximity Read ↗

gyrA/B fluoroquinolone resistance allele profiles amongst Mycobacterium tuberculosis isolates from mainland China.Semantic proximity Read ↗

Compensatory effects of M. tuberculosis rpoB mutations outside the rifampicin resistance-determining region.Semantic proximity Read ↗

Prevalence of gyrA and B gene mutations in fluoroquinolone-resistant and -sensitive clinical isolates of Mycobacterium tuberculosis and their relationship with MIC of ofloxacin.Semantic proximity Read ↗

High Proportion of Fluoroquinolone-Resistant Mycobacterium tuberculosis Isolates with Novel Gyrase Polymorphisms and a <i>gyrA</i> Region Associated with Fluoroquinolone SusceptibilitySemantic proximity Read ↗

Association of mutation patterns in gyrA/B genes and ofloxacin resistance levels in Mycobacterium tuberculosis isolates from East China in 2009.Semantic proximity Read ↗

Gyrase Mutations Are Associated with Variable Levels of Fluoroquinolone Resistance in Mycobacterium tuberculosis.Semantic proximity Read ↗

Novel gyrase mutations in quinolone-resistant and -hypersusceptible clinical isolates of Mycobacterium tuberculosis: functional analysis of mutant enzymes.Semantic proximity Read ↗

Association of <i>gyrA/B</i> mutations and resistance levels to fluoroquinolones in clinical isolates of <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.