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Article

Low-level resistance to rifampin in Streptococcus pneumoniae.

Antimicrobial agents and chemotherapy - 1 Mar 2003

Meier Patricia Stutzmann, Utz Silvia, Aebi Suzanne, Mühlemann Kathrin

Abstract excerpt

Rifampin is recommended for combination therapy of meningitis due to beta-lactam-resistant Streptococcus pneumoniae. High-level rifampin resistance (MIC, > or =4 mg/liter) has been mapped to point mutations in clusters I and III of rpoB of the pneumococcus. The molecular basis of low-level resistance (MICs, > or =0.5 and <4 mg/liter) was analyzed. Spontaneous mutants of clinical pneumococcal isolates were...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12604513
DOI: 10.1128/AAC.47.3.863-868.2003
PMCID: PMC149310

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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