Article
Double, independent mutational events in the rpsL gene of Escherichia coli: an example of hypermutability?
Molecular microbiology - 1 Jul 1993
Timms A R, Bridges B A
Abstract excerpt
A proportion (up to 20%) of newly arising streptomycin-dependent (SmD) colonies of Escherichia coli WP2 contain bacteria where, in addition to a known SmD-determining (primary) mutation in the rpsL gene, there is a further ancillary mutation in the same gene. These ancillary mutations occur at 10 sites between 11 and 201bp away from the primary mutation. Ancillary mutations have been found in mutant colonies...
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