Article
Data mining applied to linkage disequilibrium mapping.
American journal of human genetics - 1 Jul 2000
Toivonen H T, Onkamo P, Vasko K, Ollikainen V, Sevon P, Mannila H, Herr M, Kere J
Abstract excerpt
We introduce a new method for linkage disequilibrium mapping: haplotype pattern mining (HPM). The method, inspired by data mining methods, is based on discovery of recurrent patterns. We define a class of useful haplotype patterns in genetic case-control data and use the algorithm for finding disease-associated haplotypes. The haplotypes are ordered by their strength of association with the phenotype, and all...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Algorithms
- Alleles
- Child
- Child, Preschool
- Chromosome Mapping
- Computer Simulation
- Diabetes Mellitus, Type 1
- Female