A powerful likelihood method for the analysis of linkage disequilibrium between trait loci and one or more polymorphic marker loci.

Abstract excerpt

Historically, most methods for detecting linkage disequilibrium were designed for use with diallelic marker loci, for which the analysis is straightforward. With the advent of polymorphic markers with many alleles, the normal approach to their analysis has been either to extend the methodology for two-allele systems (leading to an increase in df and to a corresponding loss of power) or to select the allele...

Topics

• Alleles
• Chromosome Mapping
• Genetic Markers
• Haplotypes
• Humans
• Likelihood Functions
• Linkage Disequilibrium
• Phenotype
• Polymorphism, Genetic