Article
DMLE+: Bayesian linkage disequilibrium gene mapping.
Bioinformatics (Oxford, England) - 1 Jun 2002
Reeve Jeff P, Rannala Bruce
Abstract excerpt
SUMMARY: The program DMLE+ allows Bayesian inference of the location of a gene carrying a mutation influencing a discrete trait (such as a disease) and/or other parameters of interest (such as mutation age) based on the observed linkage disequilibrium at multiple genetic markers. DMLE+ uses either individual marker genotypes, or haplotypes, integrates over uncertain population allele frequencies, and can...
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