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Article

Subcongenic analyses reveal complex interactions between distal chromosome 4 genes controlling diabetogenic B cells and CD4 T cells in nonobese diabetic mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2012

Stolp Jessica, Chen Yi-Guang, Cox Selwyn L, Henck Vivien, Zhang Wenyu, Tsaih Shirng-Wern, Chapman Harold, Stearns Timothy, Serreze David V, Silveira Pablo A

Abstract excerpt

Autoimmune type 1 diabetes (T1D) in humans and NOD mice results from interactions between multiple susceptibility genes (termed Idd) located within and outside the MHC. Despite sharing ∼88% of their genome with NOD mice, including the H2(g7) MHC haplotype and other important Idd genes, the closely related nonobese resistant (NOR) strain fails to develop T1D because of resistance alleles in residual genomic...

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Identifiers

PMID: 22732593
DOI: 10.4049/jimmunol.1200120
PMCID: PMC3401322

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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