Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin.

The Journal of biological chemistry - 4 Aug 2000

Bhattacharyya A, Ear U S, Koller B H, Weichselbaum R R, Bishop D K

Abstract excerpt

Mutations in breast cancer tumor susceptibility genes, BRCA1 and BRCA2, predispose women to early onset breast cancer and other malignancies. The Brca genes are involved in multiple cellular processes in response to DNA damage including checkpoint activation, gene transcription, and DNA repair. Biochemical interaction with the recombinational repair protein Rad51 (Scully, R., Chen, J., Ochs, R. L., Keegan, K.,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA2 Protein
Share to Cisplatin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cross-Linking Reagents

Share to Dose-Response Relationship, Radiation

Share to Genes, BRCA1

Share to Mammary Neoplasms, Animal

Share to Rad51 Recombinase

Share to X-Rays

Source

Identifiers

PMID: 10843985
DOI: 10.1074/jbc.C000276200

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin.PMID 10843985Read ↗

Emerging roles of BRCA1 in transcriptional regulation and DNA repair.Semantic proximity Read ↗

BRCA1-associated complexes: new targets to overcome breast cancer radiation resistance.Semantic proximity Read ↗

Mammalian Rad51C contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability.Semantic proximity Read ↗

BRCA1 facilitates microhomology-mediated end joining of DNA double strand breaks.Semantic proximity Read ↗

RAD51AP1 and RAD54L Can Underpin Two Distinct RAD51-Dependent Routes of DNA Damage Repair via Homologous RecombinationSemantic proximity Read ↗

Brca1 controls homology-directed DNA repair.Semantic proximity Read ↗

Enhanced sensitivity to cisplatin and gemcitabine in Brca1-deficient murine mammary epithelial cellsSemantic proximity Read ↗

Clinical and biological significance of RAD51 expression in breast cancer: a key DNA damage response proteinSemantic proximity Read ↗

Distinct RAD51 Associations with RAD52 and BCCIP in Response to DNA Damage and Replication StressSemantic proximity Read ↗

CtBP1 transactivates RAD51 and confers cisplatin resistance to breast cancer cellsSemantic proximity Read ↗

Overexpression of RAD51 suppresses recombination defects: a possible mechanism to reverse genomic instability.Semantic proximity Read ↗

Rad51 overexpression rescues radiation resistance in BRCA2-defective cancer cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.