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Article

Rad51 overexpression rescues radiation resistance in BRCA2-defective cancer cells.

Molecular carcinogenesis - 1 Feb 2009

Brown Erika T, Holt Jeffrey T

Abstract excerpt

Breast cancers with BRCA2 mutations exhibit DNA repair defects and are particularly sensitive to radiation. BRCA2 interacts with Rad51 in a complex manner involving internal BRC and C-terminal TR2 domains which play a key role in homologous recombination. BRCA2 expression also modulates Rad51 protein levels such that Rad51 protein is relatively decreased in BRCA2-defective cancer cells. This is mediated in part...

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Source

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Identifiers

PMID: 18618591
DOI: 10.1002/mc.20463
PMCID: PMC3080251

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Rad51 overexpression rescues radiation resistance in BRCA2-defective cancer cells.PMID 18618591Read ↗

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