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Article

BRCA1-associated complexes: new targets to overcome breast cancer radiation resistance.

Expert review of anticancer therapy - 1 Feb 2006

Chen Xiaowei, Arciero Cletus A, Godwin Andrew K

Abstract excerpt

Since BRCA1 was cloned a decade ago, significant progress has been made in defining its biochemical and biological functions, as well as its role in breast and ovarian cancers. BRCA1 has been implicated in many cellular processes, including DNA repair, cell cycle checkpoint control, protein ubiquitination and chromatin remodeling. This review examines the role(s) of BRCA1 in mediating these cellular processes,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16445371
DOI: 10.1586/14737140.6.2.187

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence.

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Overview of Roles of Novel Components in the Regulation of DNA Damage Repair in BRCA1-deficient Cancers: An UpdateSemantic proximity Read ↗

BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution.Semantic proximity Read ↗

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