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CtBP1 transactivates RAD51 and confers cisplatin resistance to breast cancer cells

2 Mar 2020

Abstract excerpt

Overexpression of RAD51 is found in many cancers including breast cancer and is associated with poor survival. Compared with normal cells, RAD51 promoter is hyperactive in cancer cells indicating that RAD51 is transcriptionally activated. However, little is known about the mechanisms and factors involved in RAD51 transcription regulation. Transcription corepressor, C-terminal binding protein 1 (CtBP1), is an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32124501
DOI: 10.1002/mc.23175

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