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Article

Lack of Gata3 results in conotruncal heart anomalies in mouse.

Mechanisms of development - 1 Jan 2000

Raid Raivo, Krinka Dagni, Bakhoff Lairi, Abdelwahid Eltyeb, Jokinen Eero, Kärner Martin, Malva Merly, Meier Riho, Pelliniemi Lauri J, Ploom Merlin, Sizarov Aleksander, Pooga Margus, Karis Alar

Abstract excerpt

The transcription factor Gata3 is an important regulator of the development of thymus, the nervous system, ear, kidney, and adrenal glands. This study analyzes the role of Gata3 in the developing heart using a mouse strain containing an nlsLacZ reporter gene fused in frame to the Gata3 gene by homologous recombination. Using in situ hybridization, RT-PCR and Gata3-LacZ histochemistry, Gata3 expression was shown...

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Share to Embryo, Mammalian
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Genes, Reporter

Share to Heart Defects, Congenital

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Identifiers

PMID: 18955134
DOI: 10.1016/j.mod.2008.10.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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