Article
The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system.
Genes & development - 15 Jun 1998
Britsch S, Li L, Kirchhoff S, Theuring F, Brinkmann V, Birchmeier C, Riethmacher D
Abstract excerpt
Neuregulins (NDF, heregulin, GGF ARIA, or SMDF) are EGF-like growth and differentiation factors that signal through tyrosine kinase receptors of the ErbB family. Here, we report a novel phenotype in mice with targeted mutations in the erbB2, erbB3, or neuregulin-1 genes. These three mutations cau...
Topics
- Animals
- Antineoplastic Agents
- Aorta
- Cell Movement
- Embryo, Mammalian
- ErbB Receptors
- Ganglia, Spinal
- Gene Expression
- Genes
- Genes, erbB-2
- Glycoproteins
- Ligands
- Mesoderm
- Mice
- Mice, Inbred C57BL
- Mice, Inbred Strains
- Mutation
- Nerve Growth Factors