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Article

High levels of the p53 inhibitor MDM4 in head and neck squamous carcinomas.

Human pathology - 1 Oct 2007

Valentin-Vega Yasmine A, Barboza Juan A, Chau Gilda P, El-Naggar Adel K, Lozano Guillermina

Abstract excerpt

The p53 tumor suppressor is mutated in most human tumors. MDM2, a well-known inhibitor of p53, is overexpressed in a large number of tumors, suggesting that increased levels of MDM2 also contribute to tumorigenesis. A novel p53 inhibitor, MDM4, was more recently identified. The role of MDM4 in cancer development is not well understood. We set out to examine the levels of MDM4 by immunohistochemistry in head and...

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Topics

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Share to Blotting, Western
Share to Carcinoma, Squamous Cell
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Head and Neck Neoplasms

Share to Proto-Oncogene Proteins

Share to Proto-Oncogene Proteins c-mdm2

Share to Sequence Homology, Amino Acid

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 17651783
DOI: 10.1016/j.humpath.2007.03.005
PMCID: PMC2699677

Genes

MDM4
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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