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Article

The Roles of MDM2 and MDMX in Cancer

29 Mar 2016

Abstract excerpt

For more than 25 years, MDM2 and its homolog MDMX (also known as MDM4) have been shown to exert oncogenic activity. These two proteins are best understood as negative regulators of the p53 tumor suppressor, although they may have additional p53-independent roles. Understanding the dysregulation of MDM2 and MDMX in human cancers and how they function either together or separately in tumorigenesis may improve...

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PMID: 27022975
DOI: 10.1146/annurev-pathol-012414-040349

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