Article
MDM2 expression in areca quid chewing-associated oral squamous cell carcinomas in Taiwan.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 Jan 2001
Huang J S, Ho T J, Chiang C P, Kok S H, Kuo Y S, Kuo M Y
Abstract excerpt
MDM2 (murine double minute gene 2) overexpression has been implicated in the pathogenesis of human tumors via inhibition of the p53 tumor suppressor protein. To investigate the potential involvement of MDM2 overexpression in the pathogenesis of oral squamous cell carcinomas (SCCs) in Taiwan, we examined the expression of MDM2 protein and its relationship to p53 protein levels in 52 oral SCCs using antibodies to...
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