Article
Hyperthyroidism and Papillary Thyroid Carcinoma in Thyrotropin Receptor D633H Mutant Mice.
Thyroid : official journal of the American Thyroid Association - 1 Oct 2018
Jaeschke Holger, Undeutsch Henriette, Patyra Konrad, Löf Christoffer, Eszlinger Markus, Khalil Moosa, Jännäri Meeri, Makkonen Kristiina, Toppari Jorma, Zhang Fu-Ping, Poutanen Matti, Paschke Ralf, Kero Jukka
Abstract excerpt
BACKGROUND: Constitutively active thyrotropin receptor (TSHR) mutations are the most common etiology of non-autoimmune hyperthyroidism (NAH). Thus far, the functionality of these mutations has been tested in vitro, but the in vivo models are lacking. METHODS: To understand the pathophysiology of NAH, the patient-derived constitutively active TSHR D633H mutation was introduced into the murine Tshr by homologous...
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