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Article

In vitro generation of dendritic cells from human blood monocytes in experimental conditions compatible for in vivo cell therapy.

Journal of hematotherapy & stem cell research - 1 Apr 2000

Cao H, Vergé V, Baron C, Martinache C, Leon A, Scholl S, Gorin N C, Salamero J, Assari S, Bernard J, Lopez M

Abstract excerpt

DC are professional APC that are promising adjuvants for clinical immunotherapy. Methods to generate in vitro large numbers of functional human DC using either peripheral blood monocytes or CD34+ pluripotent HPC have been developed recently. However, the various steps of their in vitro production for further clinical use need to fit good manufacturing practice (GMP) conditions. Our study focused on setting up...

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PMID: 10813531
DOI: 10.1089/152581600319397

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