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Article

Clinical-scale generation of dendritic cells in a closed system.

Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Jan 2000

Sorg Rüdiger V, Ozcan Zakir, Brefort Thomas, Fischer Johannes, Ackermann Rolf, Müller Mirko, Wernet Peter

Abstract excerpt

Immunotherapy of malignant diseases based on dendritic cells (DCs) pulsed with tumor antigens is a promising approach. Therefore, there is a demand for large-scale, clinical-grade ex vivo generation of DCs. Here, a procedure is presented that combines monocyte selection and tissue culture in closed systems under current good manufacturing practice conditions. Leukocytes from three patients with urologic cancers...

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Source

Identifiers

PMID: 12843800
DOI: 10.1097/00002371-200307000-00010

Genes

CCR5
CCR7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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