Article
Repeated administration of cytokines improve the ex-vivo generation of human dendritic cells.
Journal of experimental & clinical cancer research : CR - 1 Dec 2004
Takeda A, Komita H, Takagi Y, Kikuchi T, Homma S, Hoshi Y, Ohno T, Horiguchi-Yamada J
Abstract excerpt
The in vitro generation of dendritic cells (DCs) enables us to practice antitumor immune therapy. Peripheral monocytes can differentiate to DCs in the presence of granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin 4 (IL-4) in vitro. To generate a large number of DCs, we compared the number of DCs generated from leukapheresis products to those from conventional blood samplings in healthy...
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