A novel approach for the generation of human dendritic cells from blood monocytes in the absence of exogenous factors.

doi:10.1016/j.jim.2008.02.021

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Article

A novel approach for the generation of human dendritic cells from blood monocytes in the absence of exogenous factors.

Journal of immunological methods - 1 Jun 2008

Schanen Brian C, Drake Donald R

Abstract excerpt

Human dendritic cells (DCs) for research and clinical applications are typically derived from purified blood monocytes that are cultured in a cocktail of cytokines for a week or more. Because it has been suggested that these cytokine-derived DCs may be deficient in some important immunological functions and might not accurately represent antigen presenting cell (APC) populations found under normal conditions in...

Topics

Cell Culture Techniques
Cell Movement
Cells, Cultured
Coculture Techniques
Cytokines
Dendritic Cells
Endothelial Cells
Gap Junctions
HLA Antigens
Humans
Immunologic Memory
Lymphocyte Activation
Membranes, Artificial
Monocytes
Phagocytosis
Phenotype
Polycarboxylate Cement
T-Lymphocytes

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Open in PubMed

Identifiers

PMID: 18423481
DOI: 10.1016/j.jim.2008.02.021

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