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Article

CIPC is a mammalian circadian clock protein without invertebrate homologues.

Nature cell biology - 1 Mar 2007

Zhao Wen-Ning, Malinin Nikolay, Yang Fu-Chia, Staknis David, Gekakis Nicholas, Maier Bert, Reischl Silke, Kramer Achim, Weitz Charles J

Abstract excerpt

At the core of the mammalian circadian clock is a feedback loop in which the heterodimeric transcription factor CLOCK-Brain, Muscle Arnt-like-1 (BMAL1) drives expression of its negative regulators, periods (PERs) and cryptochromes (CRYs). Here, we provide evidence that CLOCK-Interacting Protein, Circadian (CIPC) is an additional negative-feedback regulator of the circadian clock. CIPC exhibits circadian...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17310242
DOI: 10.1038/ncb1539

Genes

CIPC
CLOCK
BMAL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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