Article
The miRNA-192/194 cluster regulates the Period gene family and the circadian clock.
The FEBS journal - 1 Oct 2009
Nagel Remco, Clijsters Linda, Agami Reuven
Abstract excerpt
Several biological functions in mammals are regulated in a circadian fashion. The molecular mechanisms orchestrating these circadian rhythms have been unravelled. The biological clock, with its core transcriptional unit Bmal1/CLOCK, is composed of several self-sustaining feedback loops. In this study, we describe another mechanism impinging on the core components of the circadian clock. Using a forward genetic...
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