Article
Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease.
The Journal of biological chemistry - 14 Nov 2003
Murakami Kazuma, Irie Kazuhiro, Morimoto Akira, Ohigashi Hajime, Shindo Mayumi, Nagao Masaya, Shimizu Takahiko, Shirasawa Takuji
Abstract excerpt
Cerebral amyloid angiopathy (CAA) due to beta-amyloid (Abeta) is one of the specific pathological features of familial Alzheimer's disease. Abeta mainly consisting of 40- and 42-mer peptides (Abeta40 and Abeta42) exhibits neurotoxicity and aggregative abilities. All of the variants of Abeta40 and...
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