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Article

Apolipoprotein E genotype regulates amyloid-beta cytotoxicity.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 6 Apr 2005

Wilhelmus Micha M M, Otte-Höller Irene, Davis Judianne, Van Nostrand William E, de Waal Robert M W, Verbeek Marcel M

Abstract excerpt

The epsilon4 allele of apolipoprotein E (ApoE) is a risk factor for Alzheimer's disease (AD), whereas the epsilon2 allele may be relatively protective. Both alleles are risk factors for cerebral amyloid angiopathy (CAA)-related hemorrhages. CAA is associated with degeneration of smooth muscle cells and pericytes. Previously, we described that synthetic amyloid-beta1-40 peptide (Abeta1-40) with the 22Glu--> Gln...

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Identifiers

PMID: 15814793
DOI: 10.1523/JNEUROSCI.4213-04.2005
PMCID: PMC6725371

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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