Studies on the first described Alzheimer's disease amyloid beta mutant, the Dutch variant.

Abstract excerpt

Amyloid protein deposited in cerebral vessel walls and diffuse plaques of patients with hereditary cerebral hemorrhage with amyloidosis, Dutch type (HCHWA-D), is similar to the 40-42 residues amyloid beta (Abeta) in vessel walls and senile plaques in brains of patients with Alzheimer's disease (AD), Down's syndrome, and familial and sporadic cerebral amyloid angiopathy (CAA). In 1990 we sequenced the amyloid...

Topics

• Alzheimer Disease
• Amyloid beta-Protein Precursor
• Brain
• Genetic Variation
• Humans
• Netherlands
• Point Mutation