Article
Using chiral peptide substitutions to probe the structure function relationship of a key residue of Aβ42.
Chirality - 1 Jan 2017
Warner Christopher J A, Dutta Subrata, Foley Alejandro R, Chen Eefei, Kliger David S, Raskatov Jevgenij A
Abstract excerpt
Amyloid beta-protein 42 plays an important role in the onset and progression of Alzheimer's disease. Familial mutations have identified the glutamate residue 22 as a hotspot with regard to peptide neurotoxicity. We introduce an approach to study the influence of systematic sidechain modification at this residue, employing chirality as a structural probe. Circular dichroism experiments reveal that...
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