Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dutch and Arctic mutant peptides of beta amyloid(1-40) differentially affect the FGF-2 pathway in brain endothelium.

Experimental cell research - 1 Feb 2009

Solito Raffaella, Corti Federico, Fossati Silvia, Mezhericher Emiliya, Donnini Sandra, Ghiso Jorge, Giachetti Antonio, Rostagno Agueda, Ziche Marina

Abstract excerpt

Single point mutations of the amyloid precursor protein generate Abeta variants bearing amino acid substitutions at positions 21-23. These mutants are associated with distinct hereditary phenotypes of cerebral amyloid angiopathy, manifesting varying degrees of tropism for brain vessels, and impaired microvessel remodeling and angiogenesis. We examined the differential effects of E22Q (Dutch), and E22G (Arctic)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Peptides
Share to Apoptosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endothelial Cells

Share to Endothelium, Vascular

Share to Fibroblast Growth Factor 2

Share to Microvessels

Share to Peptide Fragments

Share to Receptor, Fibroblast Growth Factor, Type 1

Source

Open in PubMed Open full text

Identifiers

PMID: 19061884
DOI: 10.1016/j.yexcr.2008.11.002
PMCID: PMC2764262

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dutch and Arctic mutant peptides of beta amyloid(1-40) differentially affect the FGF-2 pathway in brain endothelium.PMID 19061884Read ↗

Anti-angiogenic activity of the mutant Dutch A(beta) peptide on human brain microvascular endothelial cells.Semantic proximity Read ↗

Substitutions at codon 22 of Alzheimer's abeta peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells.Semantic proximity Read ↗

Charge alterations of E22 enhance the pathogenic properties of the amyloid beta-protein.Semantic proximity Read ↗

Studies on the first described Alzheimer's disease amyloid beta mutant, the Dutch variant.Semantic proximity Read ↗

Pathogenic effects of cerebral amyloid angiopathy mutations in the amyloid beta-protein precursor.Semantic proximity Read ↗

Potent anti-angiogenic motifs within the Alzheimer beta-amyloid peptide.Semantic proximity Read ↗

Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease.Semantic proximity Read ↗

Toxicity of Dutch (E22Q) and Flemish (A21G) mutant amyloid beta proteins to human cerebral microvessel and aortic smooth muscle cells.Semantic proximity Read ↗

Amyloid β in hereditary cerebral hemorrhage with amyloidosis-Dutch type.Semantic proximity Read ↗

Alzheimer’s amyloid β heterogeneous species differentially affect brain endothelial cell viability, blood‐brain barrier integrity, and angiogenesisSemantic proximity Read ↗

Dutch, Flemish, Italian, and Arctic mutations of APP and resistance of Abeta to physiologically relevant proteolytic degradation.Semantic proximity Read ↗

Hereditary cerebral hemorrhage with amyloidosis-Dutch type.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.