Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Toxicity of Dutch (E22Q) and Flemish (A21G) mutant amyloid beta proteins to human cerebral microvessel and aortic smooth muscle cells.

Stroke - 1 Feb 2000

Wang Z, Natté R, Berliner J A, van Duinen S G, Vinters H V

Abstract excerpt

BACKGROUND AND PURPOSE: Cerebral amyloid angiopathy (CAA) is characterized by the deposition of amyloid beta protein (Abeta) in cortical and leptomeningeal vessels of patients with Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis, Dutch type. Smooth muscle cells (SMC) from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Peptides
Share to Aorta
Share to Brain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Division

Share to Cell Survival

Share to Microcirculation

Share to Muscle, Smooth, Vascular

Share to Peptides

Source

Identifiers

PMID: 10657433
DOI: 10.1161/01.str.31.2.534

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10657433-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Toxicity of Dutch (E22Q) and Flemish (A21G) mutant amyloid beta proteins to human cerebral microvessel and aortic smooth muscle cells.PMID 10657433Read ↗

Dutch and Arctic mutant peptides of beta amyloid(1-40) differentially affect the FGF-2 pathway in brain endothelium.Semantic proximity Read ↗

Rapid Degeneration of Cultured Human Brain Pericytes by Amyloid β ProteinSemantic proximity Read ↗

Charge alterations of E22 enhance the pathogenic properties of the amyloid beta-protein.Semantic proximity Read ↗

Substitutions at codon 22 of Alzheimer's abeta peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells.Semantic proximity Read ↗

Toxicity of various amyloid beta peptide species in cultured human blood-brain barrier endothelial cells: increased toxicity of dutch-type mutant.Semantic proximity Read ↗

Differential activation of mitochondrial apoptotic pathways by vasculotropic amyloid-beta variants in cells composing the cerebral vessel walls.Semantic proximity Read ↗

Amyloid-beta-induced degeneration of human brain pericytes is dependent on the apolipoprotein E genotype.Semantic proximity Read ↗

Pathogenic effects of cerebral amyloid angiopathy mutations in the amyloid beta-protein precursor.Semantic proximity Read ↗

Pathogenic A beta induces the expression and activation of matrix metalloproteinase-2 in human cerebrovascular smooth muscle cells.Semantic proximity Read ↗

Tauroursodeoxycholic acid prevents E22Q Alzheimer's Abeta toxicity in human cerebral endothelial cells.Semantic proximity Read ↗

Pathogenic effects of D23N Iowa mutant amyloid beta -protein.Semantic proximity Read ↗

Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.