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Article

Regulation of human telomerase RNA biogenesis and localization.

RNA biology - 1 Mar 2021

Qin Jian, Autexier Chantal

Abstract excerpt

Maintenance of telomeres is essential for genome integrity and replicative capacity in eukaryotic cells. Telomerase, the ribonucleoprotein complex that catalyses telomere synthesis is minimally composed of a reverse transcriptase and an RNA component. The sequence and structural domains of human telomerase RNA (hTR) have been extensively characterized, while the regulation of hTR transcription, maturation, and...

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Methylation
Nucleic Acid Conformation
RNA
RNA Caps
RNA Processing, Post-Transcriptional
RNA Stability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32813614
DOI: 10.1080/15476286.2020.1809196
PMCID: PMC7954027

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