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Article

A self-regulating template in human telomerase.

Proceedings of the National Academy of Sciences of the United States of America - 5 Aug 2014

Brown Andrew F, Podlevsky Joshua D, Qi Xiaodong, Chen Yinnan, Xie Mingyi, Chen Julian J-L

Abstract excerpt

Telomerase is a specialized reverse transcriptase (RT) containing an intrinsic telomerase RNA (TR) component. It synthesizes telomeric DNA repeats, (GGTTAG)n in humans, by reiteratively copying a precisely defined, short template sequence from the integral TR. The specific mechanism of how the telomerase active site uses this short template region accurately and efficiently during processive DNA repeat synthesis...

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Identifiers

PMID: 24982163
DOI: 10.1073/pnas.1402531111
PMCID: PMC4128165

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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