Article
Dominant-lethal alpha-tubulin mutants defective in microtubule depolymerization in yeast.
Molecular biology of the cell - 1 Dec 2001
Anders K R, Botstein D
Abstract excerpt
The dynamic instability of microtubules has long been understood to depend on the hydrolysis of GTP bound to beta-tubulin, an event stimulated by polymerization and necessary for depolymerization. Crystallographic studies of tubulin show that GTP is bound by beta-tubulin at the longitudinal dimer-dimer interface and contacts particular alpha-tubulin residues in the next dimer along the protofilament. This...
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