Article

Modeling disease-correlated TUBA1A mutation in budding yeast reveals a molecular basis for tubulin dysfunction

2020-04-14

Abstract excerpt

Malformations of cortical development (MCD) of the human brain are a likely consequence of defective neuronal migration, and/or proliferation of neuronal progenitor cells, both of which are dictated in part by microtubule-dependent transport of various cargoes, including the mitotic spindle. Throughout the evolutionary spectrum, proper spindle positioning depends on cortically anchored dynein motors that exert for...

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Literature Corpus work: 356e3fed-4660-5203-bb5a-bda55087174d
DOI: 10.1101/2020.04.13.039982

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