Article
HMSH6 alterations in patients with microsatellite instability-low colorectal cancer.
Cancer research - 15 Apr 2000
Parc Y R, Halling K C, Wang L, Christensen E R, Cunningham J M, French A J, Burgart L J, Price-Troska T L, Roche P C, Thibodeau S N
Abstract excerpt
Two microsatellite instability (MSI) phenotypes have been described in colorectal cancer (CRC): MSI-H (instability at >30% of the loci examined) and MSI-L (MSI at 1-30% of the loci examined). The MSI-H phenotype, observed in both hereditary nonpolyposis colon cancer-associated CRC and approximately 15% of sporadic CRC, generally results from mutational or epigenetic inactivation of the DNA mismatch repair (MMR)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.