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Article

Molecular pathways: microsatellite instability in colorectal cancer: prognostic, predictive, and therapeutic implications.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2012

Sinicrope Frank A, Sargent Daniel J

Abstract excerpt

Microsatellite instability (MSI) is the molecular fingerprint of the deficient mismatch repair (MMR) system, which characterizes ∼15% of colorectal cancers. MSI develops as a result of germline mutations in MMR genes or, more commonly, from epigenetic silencing of MLH1 in sporadic tumors occurring in a background of methylation of CpG islands in gene promoter regions and in tumors that frequently show hotspot...

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Source

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Identifiers

PMID: 22302899
DOI: 10.1158/1078-0432.CCR-11-1469
PMCID: PMC3306518

Genes

BRAF
MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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