Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alterations of the INK4a/ARF locus in human intracranial germ cell tumors.

Cancer research - 15 Apr 2000

Iwato M, Tachibana O, Tohma Y, Arakawa Y, Nitta H, Hasegawa M, Yamashita J, Hayashi Y

Abstract excerpt

Little is known about the molecular mechanisms responsible for the development of intracranial germ cell tumors (ICGTs). Recently, we demonstrated that the balance of the p53-mdm2 interactions is disrupted in ICGTs. The p14ARF product, a tumor suppresser gene located on the INK4a/ARF locus, acts as one of the major factors affecting p53-mdm2 interactions via its binding to mdm2 and the stimulation of mdm2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to Cyclin-Dependent Kinase Inhibitor p16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Frameshift Mutation

Share to Germinoma

Share to Neoplasms, Germ Cell and Embryonal

Share to Polymorphism, Single-Stranded Conformational

Share to Sequence Deletion

Share to Tumor Suppressor Protein p14ARF

Source

Identifiers

PMID: 10786670

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alterations of the INK4a/ARF locus in human intracranial germ cell tumors.PMID 10786670Read ↗

Novel molecular subtypes of intracranial germ cell tumors expand therapeutic opportunities.Semantic proximity Read ↗

Molecular analysis for p53 and mdm2 in intracranial germ cell tumors.Semantic proximity Read ↗

Novel somatic and germline mutations in intracranial germ cell tumours.Semantic proximity Read ↗

Genome-wide methylation profiles in primary intracranial germ cell tumors indicate a primordial germ cell origin for germinomas.Semantic proximity Read ↗

Genome-wide analysis of DNA copy number alterations and loss of heterozygosity in intracranial germ cell tumors.Semantic proximity Read ↗

Mutually exclusive mutations of KIT and RAS are associated with KIT mRNA expression and chromosomal instability in primary intracranial pure germinomas.Semantic proximity Read ↗

p53 gene mutation and ink4a-arf deletion appear to be two mutually exclusive events in human glioblastomaSemantic proximity Read ↗

KRAS Mutation in Pediatric Intracranial Germ Cell Tumors.Semantic proximity Read ↗

c-kit gene mutations in intracranial germinomas.Semantic proximity Read ↗

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.Semantic proximity Read ↗

INK4a/ARFLocus Alterations in Human Non-Hodgkin's Lymphomas Mainly Occur in Tumors with Wild-Type p53 GeneSemantic proximity Read ↗

The detection of p53 gene mutation using a microdissection technique in primary intracranial germ cell tumors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.