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Article

c-kit gene mutations in intracranial germinomas.

Cancer science - 1 Sept 2004

Sakuma Yuji, Sakurai Shinji, Oguni Sachiko, Satoh Masaaki, Hironaka Mitsugu, Saito Ken

Abstract excerpt

Gain-of-function mutations of the c-kit gene and the expression of phosphorylated KIT are found in most gastrointestinal stromal tumors and mastocytosis. Further, almost all gonadal seminomas/dysgerminomas exhibit KIT membranous staining, and several reports have clarified that some (10-25%) have a c-kit gene mutation. But, whether intracranial germinomas also have a c-kit gene mutation remains unsolved. To...

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Source

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Identifiers

PMID: 15471556
DOI: 10.1111/j.1349-7006.2004.tb03251.x
PMCID: PMC11160023

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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