Article
Mutually exclusive mutations of KIT and RAS are associated with KIT mRNA expression and chromosomal instability in primary intracranial pure germinomas.
Acta neuropathologica - 1 Jan 2014
Fukushima Shintaro, Otsuka Ayaka, Suzuki Tomonari, Yanagisawa Takaaki, Mishima Kazuhiko, Mukasa Akitake, Saito Nobuhito, Kumabe Toshihiro, Kanamori Masayuki, Tominaga Teiji, Narita Yoshitaka, Shibui Soichiro, Kato Mamoru, Shibata Tatsuhiro, Matsutani Masao, Nishikawa Ryo, Ichimura Koichi
Abstract excerpt
Intracranial germ cell tumors (iGCTs) are the second most common brain tumors among children under 15 in Japan. The pathogenesis of iGCTs is largely unexplored. Although a subset of iGCTs is known to have KIT mutation, its impact on the biology and patients' survival has not been established. In this study, we investigated genes involved in the KIT signaling pathway. 65 iGCTs (30 pure germinomas, 14 teratomas, 18...
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