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Article

ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation.

The Journal of biological chemistry - 7 Jul 2000

She Q B, Chen N, Dong Z

Abstract excerpt

Phosphorylation of the p53 tumor suppressor protein is likely to play an important role in regulating its activity. Serine 15 phosphorylation of p53 leads to a stabilization of p53 by reducing its interaction with murine double minute 2, a negative regulatory partner. Recently, p53 was reported to be activated and phosphorylated at serine 15 following UV radiation. However, the signaling pathway that mediates...

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PMID: 10781582
DOI: 10.1074/jbc.M001020200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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