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Article

Hypoxia Links ATR and p53 through Replication Arrest

1 Mar 2002

Abstract excerpt

Previous studies have demonstrated that phosphorylation of human p53 on serine 15 contributes to protein stabilization after DNA damage and that this is mediated by the ATM family of kinases. However, cellular exposure to hypoxia does not induce any detectable level of DNA lesions compared to ionizing radiation, and the oxygen dependency of p53 protein accumulation differs from that of HIF-1, the...

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Identifiers

PMID: 11865061
DOI: 10.1128/mcb.22.6.1834-1843.2002

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