Article
p53 tumor suppressor gene: a critical molecular target for UV induction and prevention of skin cancer.
Photochemistry and photobiology - 1 Jan 2000
Benjamin Cara L, Ullrich Stephen E, Kripke Margaret L, Ananthaswamy Honnavara N
Abstract excerpt
The relationship between exposure to UV radiation and development of skin cancer has been well established. Several studies have shown that UVB induces unique mutations (C-->T and CC-->TT transitions) in the p53 tumor suppressor gene that are not commonly induced by other carcinogens. Our studies...
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